pI: 7.1064 |
Length (AA): 160 |
MW (Da): 18326 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_126711)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G63080 | glutathione peroxidase 5 |
Arabidopsis thaliana | AT1G63460 | glutathione peroxidase 8 |
Arabidopsis thaliana | AT4G11600 | glutathione peroxidase 6 |
Arabidopsis thaliana | AT2G25080 | phospholipid hydroperoxide glutathione peroxidase 1 |
Arabidopsis thaliana | AT2G31570 | glutathione peroxidase GPx |
Arabidopsis thaliana | AT2G48150 | glutathione peroxidase 4 |
Arabidopsis thaliana | AT4G31870 | glutathione peroxidase 7 |
Arabidopsis thaliana | AT2G43350 | glutathione peroxidase 3 |
Brugia malayi | Bm1_30395 | Probable phospholipid hydroperoxide glutathione peroxidase |
Candida albicans | CaO19.11915 | similar to S. cerevisiae GPX2 (YBR244W) phospholipid hydroperoxide glutathione peroxidase |
Candida albicans | CaO19.4436 | similar to S. cerevisiae GPX2 (YBR244W) phospholipid hydroperoxide glutathione peroxidase |
Candida albicans | CaO19.7731 | one of four potential glutathione peroxidase genes |
Candida albicans | CaO19.86 | one of four potential glutathione peroxidase genes |
Candida albicans | CaO19.85 | one of four potential glutathione peroxidase genes |
Candida albicans | CaO19.7730 | one of four potential glutathione peroxidase genes |
Caenorhabditis elegans | CELE_R05H10.5 | Protein GPX-2 |
Caenorhabditis elegans | CELE_R03G5.5 | Protein GPX-7, isoform B |
Caenorhabditis elegans | CELE_T09A12.2 | Protein GPX-6, isoform A |
Caenorhabditis elegans | CELE_F26E4.12 | Protein GPX-1 |
Cryptosporidium hominis | Chro.30063 | glutathione peroxidase |
Cryptosporidium parvum | cgd3_460 | glutathione peroxidase |
Drosophila melanogaster | Dmel_CG12013 | CG12013 gene product from transcript CG12013-RC |
Escherichia coli | b1710 | glutathione peroxidase |
Echinococcus granulosus | EgrG_000374800 | phospholipid hydroperoxide glutathione |
Homo sapiens | 493869 | glutathione peroxidase 8 (putative) |
Homo sapiens | ENSG00000116157 | glutathione peroxidase 7 |
Homo sapiens | ENSG00000167468 | glutathione peroxidase 4 |
Leishmania braziliensis | LbrM.26.0830 | glutathione peroxidase-like protein, putative |
Leishmania braziliensis | LbrM.26.0820 | glutathione peroxidase-like protein, putative |
Leishmania donovani | LdBPK_260780.1 | glutathione peroxidase-like protein, putative |
Leishmania infantum | LinJ.26.0770 | glutathione peroxidase-like protein, putative |
Leishmania infantum | LinJ.26.0780 | glutathione peroxidase-like protein, putative |
Leishmania major | LmjF.26.0810 | type II (glutathione peroxidase-like) tryparedoxin peroxidase |
Leishmania major | LmjF.26.0800 | type II (glutathione peroxidase-like) tryparedoxin peroxidase |
Leishmania major | LmjF.26.0820 | type II (glutathione peroxidase-like) tryparedoxin peroxidase |
Leishmania mexicana | LmxM.26.0800 | type II (glutathione peroxidase-like) tryparedoxin peroxidase |
Leishmania mexicana | LmxM.26.0810 | type II (glutathione peroxidase-like) tryparedoxin peroxidase |
Loa Loa (eye worm) | LOAG_10617 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10618 | glutathione peroxidase |
Loa Loa (eye worm) | LOAG_05492 | hypothetical protein |
Mus musculus | ensembl-mmu:ENSMUSG00000021760 | glutathione peroxidase 8 (putative) |
Mus musculus | 67305 | glutathione peroxidase 7 |
Mus musculus | ENSMUSG00000075706 | glutathione peroxidase 4 |
Neospora caninum | NCLIV_048080 | Glutathione peroxidase, related |
Oryza sativa | 4332876 | Os03g0358100 |
Oryza sativa | 4336627 | Os04g0556300 |
Oryza sativa | 4330235 | Os02g0664000 |
Oryza sativa | 4340341 | Os06g0185900 |
Oryza sativa | 4350287 | Os11g0284900 |
Onchocerca volvulus | OVOC53 | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial homolog |
Plasmodium berghei | PBANKA_0610500 | glutathione peroxidase-like thioredoxin peroxidase |
Plasmodium falciparum | PF3D7_1212000 | glutathione peroxidase-like thioredoxin peroxidase |
Plasmodium knowlesi | PKNH_1234400 | glutathione peroxidase-like thioredoxin peroxidase, putative |
Plasmodium knowlesi | PKNH_1312100 | glutathione peroxidase-like thioredoxin peroxidase, putative |
Plasmodium vivax | PVX_084630 | glutathione peroxidase-like thioredoxin peroxidase, putative |
Saccharomyces cerevisiae | YBR244W | glutathione peroxidase GPX2 |
Saccharomyces cerevisiae | YIR037W | peroxiredoxin HYR1 |
Saccharomyces cerevisiae | YKL026C | glutathione peroxidase GPX1 |
Schistosoma japonicum | Sjp_0218220 | ko:K00432 glutathione peroxidase [EC1.11.1.9], putative |
Schmidtea mediterranea | mk4.015133.00 | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial |
Schmidtea mediterranea | mk4.003305.03 | |
Trypanosoma brucei gambiense | Tbg972.7.1100 | trypanothione/tryparedoxin dependent peroxidase 3,glutathione peroxidase-like protein 3, putative |
Trypanosoma brucei | Tb927.7.1140 | trypanothione/tryparedoxin dependent peroxidase 3 |
Trypanosoma brucei | Tb927.7.1130 | trypanothione/tryparedoxin dependent peroxidase 2 |
Trypanosoma congolense | TcIL3000_0_04430 | trypanothione/tryparedoxin dependent peroxidase 1, cytosolic |
Trypanosoma congolense | TcIL3000_0_04420 | trypanothione/tryparedoxin dependent peroxidase 1, cytosolic |
Trypanosoma cruzi | TcCLB.507515.10 | glutathione peroxidase-like protein, putative |
Trypanosoma cruzi | TcCLB.503899.110 | glutathione peroxidase-like protein, putative |
Trypanosoma cruzi | TcCLB.507515.4 | trypanothione/tryparedoxin dependent peroxidase 2, putative |
Trypanosoma cruzi | TcCLB.503899.119 | trypanothione/tryparedoxin dependent peroxidase 2, putative |
Trypanosoma cruzi | TcCLB.503899.130 | glutathione peroxidase-like protein, putative |
Toxoplasma gondii | TGME49_266130 | peroxiredoxin PRX2 |
Toxoplasma gondii | TGME49_266120 | thioredoxin-dependent peroxidase TPX1/2 |
Trichomonas vaginalis | TVAG_248810 | glutathione peroxidase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b1710 | Escherichia coli | non-essential | goodall |
CELE_F26E4.12 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F26E4.12 | Caenorhabditis elegans | larval arrest | wormbase |
TGME49_266120 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_266130 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_266120 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_266130 | Toxoplasma gondii | Probably non-essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.